CASE – 08

Following his third episode of gouty arthritis, a 50-year-old man sees you in the clinic. Each case was successfully treated acutely; however, your patient is interested in trying to prevent future episodes. He is not on regular medications and has a normal physical examination today. Blood work reveals an elevated serum uric acid level and otherwise normal renal function and electrolytes. A 24-hour urine collection for uric acid reveals that he is under-excreting uric acid. Suspecting that this is the cause of his recurrent gout, you place him on probenecid.

1) What is the mechanism of action of probenecid?

2) Which drugs could have their excretion inhibited by probenecid?

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