CASE – 06

A 70-year-old man is seen in follow-up at your office after he has been hospitalized for a myocardial infarction (MI). He underwent successful angioplasty and is currently asymptomatic. Prior to his MI, he was not on medications. He is not a smoker and is not diabetic. During his hospitalization, he was noted to have persistently elevated blood pressure readings. He had asthma as a child, but has not had any recent wheezing episodes. While in the hospital, he was started on oral metoprolol.

1) Metoprolol is selective for which adrenoceptor?

2) What effects do agents such as metoprolol have on the cardiovascular system?

3) In which organ is metoprolol primarily metabolized?

4) Why must b-adrenergic antagonists be used with caution in asthmatics?

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