CASE-01

A 12-year-old girl presents to your office with a sore throat and fever. You diagnose her with pharyngitis caused by group A  beta-hemolytic Streptococcus. She is given an IM injection of penicillin. Approximately 5 minutes later, she is found to be in respiratory distress and audibly wheezing. Her skin is mot- tled and cool, she is tachycardic (rapid heart rate), and her blood pressure has fallen to 70/20 mm Hg. You immediately diagnose her as having an anaphy- lactic reaction to the penicillin and give an SC injection of epinephrine.

1) What effect will epinephrine have on this patient’s vascular system?

2) Which adrenoceptor primarily mediates the vascular response?

3) What effect will epinephrine have on her respiratory system?

4) Which adrenoceptor primarily mediates the respiratory system response?

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